منابع مشابه
Sorting Sloppy Sonic
In the classic picture of morphogen-mediated patterning, cells acquire the correct spatial arrangement of specified fates by reading a precisely distributed gradient of morphogen. Xiong et al. now provide evidence for an alternate strategy-cells of the zebrafish neural tube actively sort to their correct positions following disordered specification by Sonic hedgehog.
متن کاملSloppy Identity
Although sloppy interpretation is usually accounted for by theories of ellipsis, it often arises in non-elliptical contexts. In this paper, a theory of sloppy interpretation is provided which captures this fact. The underlying idea is that sloppy interpretation results from a semantic constraint on parallel structures and the theory is shown to predict sloppy readings for deaccented and paychec...
متن کاملSortilin regulates sorting and secretion of Sonic hedgehog.
Sonic Hedgehog (Shh) is a secreted morphogen that is an essential regulator of patterning and growth. The Shh full-length protein undergoes autocleavage in the endoplasmic reticulum to generate the biologically active N-terminal fragment (ShhN), which is destined for secretion. We identified sortilin (Sort1), a member of the VPS10P-domain receptor family, as a new Shh trafficking receptor. We d...
متن کاملA Selectable Sloppy Heap
We study the selection problem, namely that of computing the ith order statistic of n given elements. Here we offer a data structure called selectable sloppy heap handling a dynamic version in which upon request: (i) a new element is inserted or (ii) an element of a prescribed quantile group is deleted from the data structure. Each operation is executed in (ideal!) constant time— and is thus in...
متن کاملA sloppy checkpoint
Muscle f irst in neurodegenerative disease? R esearchers hunting for the molecular malfunction behind the paralyzing disease spinal muscular atrophy (SMA) might have been looking on the wrong side of the neuromuscular junction, as Rajendra et al. show on page 831. The work suggests that reduced levels of SMA’s signature protein, SMN, disrupt the junction from the muscle side. SMA is the second ...
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ژورنال
عنوان ژورنال: Cell
سال: 2013
ISSN: 0092-8674
DOI: 10.1016/j.cell.2013.04.021